Stud Health Technol Inform. 2020 Jun 26;272:205-208. doi: 10.3233/SHTI200530.

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Using PM-TOM for the Minimization of Adverse Drug and Gene Interactions in Therapies for Common Multi-Diseases

 

Adnan KULENOVIC, Azra LAGUMDZIJA-KULENOVIC

A ! A – Absolute Information Age, Inc. Toronto, Canada.

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Multiple studies show that multi-disease therapies can lead to dangerous reactions and high healthcare costs due to their adverse drug-drug, drug-gene, and drug-condition interactions. This paper presents the results of using PM-TOM (Personalized Medicine Therapy Optimization Method) to find therapies that minimize these interactions. We tested the method on the repository of electronic medical records of the Harvard Personal Genome Project (PGP) and the public databases of drug and genetic information: DrugBank and Comprehensive Toxicogenomics Database (CTD). The results presented in this paper showed a significant potential of PM-TOM for reducing the cumulative adverse drug interactions in therapies for common multi-diseases.

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Keywords: Adverse Drug Reactions (ADR); Clinical Decision Support Systems (CDSS); Drug-Condition Interactions (DCI); Drug-Drug Interactions (DDI); Drug-Gene Interactions (DGI); Electronic Medical Records (EMR); Multi-diseases; Personalized Medicine; Polypharmacy Therapies.

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https://pubmed.ncbi.nlm.nih.gov/32604637/

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