PM-TOM Functions
1. Analyze and Optimize Your Polypharmacy Treatments
PM-TOM optimizes polypharmacy treatments for 69 prevalent diseases by analyzing 660 medications and 450 frequent drug effects. Given a wide range of available pharmacological options, PM-TOM systematically selects medications that minimize adverse drug reactions and drug interactions, promoting safer treatment strategies.
The optimization report provides a detailed analysis of drug-drug interactions (DDIs), drug-condition interactions (DCIs), drug-food interactions (DFIs), and drug-gene interactions (DGIs). It identifies potential risks according to the Beers criteria at both the individual drug and interaction levels. Additionally, the system detects possible prescription cascades. The Illustrative Examples sections include preset data for several polypharmacy treatment scenarios, offering a structured introduction to the application’s functionalities, as well as a case with patient genetic data and a case with prescription cascades.
Basic Optimization lets you enter suspected ADRs, diseases, and medication candidates, producing a core analytical report. At the same time, the Extended Optimization lets you retrieve previously submitted treatments and enter reporting options, including DFIs, Beers Criteria warnings, and prescription cascades. It directly interacts with ChatGPT to get medication alternatives, provide treatment reviews and answer various questions. Additional examples further illustrate various PM-TOM features.
PM-TOM enables the development of multiple treatment versions for polypharmacy management. This functionality compares drug reactions and interactions across various treatment versions, enabling doctors to make treatment decisions based on a detailed analysis of their ADRs and drug interactions.
3. Create a Deprescribing Plan with AI Support
Deprescribing is a critical process aimed at adjusting, reducing, or discontinuing medications to improve treatment safety and patient outcomes in cases of polypharmacy. Through ChatGPT-assisted analysis, PM-TOM can generate structured deprescribing plans, ensuring a systematic transition between medication regimens while maintaining therapeutic efficacy.
4. Consult AI about the polypharmacy treatment details
Furthermore, the system integrates ChatGPT support, allowing users to explore alternative treatment options based on suspected ADRs in patients, examine pharmacokinetic and pharmacodynamic properties, and refine treatment plans accordingly.